DIRECT SCIENCES: SOLVING PROBLEMS THROUGH SCIENTIFIC NETWORKING

Hypertension, an outstanding danger factor for different cardiovascular, fringe vascular and renal occasions is a significant general wellbeing challenge. Reninangiotensin framework being the most essential pathogenic system of hypertension is interceded by a key segment, the angiotensin converting enzyme. The aim of current study was to know the relationship of hypertensive patients with angiotensin converting enzyme gene polymorphism. Total 65 clinically analyzed hypertensive patients with no related sickness condition and five age and sex coordinated clearly sound controls were included in the current study. Polymerase chain reaction was used for the amplification of intron number 16 of Angiotensin converting enzy megene harboring the 287 bp Alu repeat sequence. Homozygous Deletion/Deletion, Insertion/Insertion and heterozygous Insertion/Deletion were the three possible genotypes which were analyzed. After the amplification of products, 2% agarose gel was used for the separation of products. Statistical Package for the Social Sciences 20 (SPSS 20) was used for the statistical analysis; the P value was found non-significant and to avoid any false positive or false negative significance we cannot conclude any result.

Insertion; deletion; renin angiotensin system; total peripheral resistance; blood pressure

Hyphaene thebaica and Medemia argun are very important desert plants not only as sources of nutrients for human and animal nutrition, but also as potential sources of antioxidant and antimicrobial secondary metabolites agents such as polyphenolics including protoanthocyanidins, flavonoids and phenolics in addition to other classes of secondary metabolites such as alkaloids and saponins. The recently discovering biological activity of H. thebaica has increased its importance. Having very narrow ecological amplitude, M. argun has received very little attention from researchers. The description of M. argun as endangered species may also contributed to decreasing the number of studies on Medemia. The objective of this paper is to review the phytochemistry and biological activity of both H. thebaica and M. argun. The biological activity of both plants will be discussed and evaluated in terms of the content of secondary metabolites in their extracts. Till now M. argun has not been biologically exploited yet although it has diverse arrays from active secondary metabolites in different parts of the plant.

Hyphaene thebaica; Medemia argun; Secondary metabolites; Polyphenolics; Antioxidants; Anticancer activity; Antimicrobial activity